How fat cell development affects obesity and diabetes
Regulation of Mesenchymal Progenitor Cell Fate and Adipose Tissue Remodeling
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-11073853
This study looks at how certain cells in fat tissue change when someone is obese and how these changes might lead to problems like type 2 diabetes, with the goal of finding new ways to help improve health and reduce inflammation for people dealing with these issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11073853 on ClinicalTrials.gov |
What this research studies
This research investigates how mesenchymal progenitor cells in adipose tissue change during obesity and their role in metabolic diseases like type 2 diabetes. It focuses on understanding how these cells respond to environmental factors and contribute to inflammation and fat cell development. By studying the mechanisms behind adipose tissue remodeling, the research aims to identify potential new therapies that could improve metabolic health and reduce chronic inflammation in patients. The approach includes analyzing specific cell populations and their gene expressions related to obesity and diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing obesity or related metabolic disorders, particularly those at risk for type 2 diabetes.
Not a fit: Patients who are not affected by obesity or metabolic diseases may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve metabolic health and reduce the risk of diabetes and related diseases.
How similar studies have performed: Other research has shown promising results in understanding the role of adipose tissue in metabolic diseases, indicating that this approach could lead to significant advancements.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SEALE, PATRICK — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: SEALE, PATRICK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus, atherosclerotic coronary disease