How Fat cadherins control tissue growth and organ shape
Regulation of tissue growth and morphogenesis by Fat cadherins
This study is looking at how certain proteins help shape and grow organs during development, using fruit flies to learn more about how problems with these proteins can lead to birth defects and cancer, which could eventually help us find new ways to treat these issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-10929403 on NIH RePORTER |
What this research studies
This research investigates how specific proteins called Fat cadherins influence the growth and shape of organs during development. By studying the fruit fly Drosophila, researchers aim to understand the mechanisms behind tissue growth and morphogenesis, particularly how mutations in these proteins can lead to developmental defects and cancers. The study will explore the role of these proteins in regulating cell signaling pathways and how they affect the organization of cells within tissues. This research could provide insights into congenital defects and cancer development, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital developmental defects or those at risk for cancers associated with mutations in Fat cadherins.
Not a fit: Patients with unrelated genetic conditions or those not affected by developmental defects or cancers linked to Fat cadherins may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for congenital developmental defects and certain cancers.
How similar studies have performed: Previous research has shown success in using model organisms like Drosophila to uncover fundamental biological processes, suggesting that this approach could yield valuable insights.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Misra, Jyoti R. — State University New York Stony Brook
- Study coordinator: Misra, Jyoti R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.