How Factor XIIa may trigger renin in heart failure
Factor XIIa is the long-sought activator of circulating renin in heart failure.
This project tests whether a blood-clotting enzyme called Factor XIIa turns on renin in people with heart failure whose hearts pump less strongly.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-11110479 on NIH RePORTER |
What this research studies
From my point of view as a patient, the team is trying to find out if Factor XIIa causes the hormone renin to become active in the bloodstream, which can worsen heart failure. They will study the enzyme and its effects in the lab, measure renin and related biomarkers in blood samples, and use animal models of dilated cardiomyopathy to see how FXIIa influences disease. The researchers will also try molecular interventions that block FXIIa to observe whether that prevents renin activation and heart damage. Together these steps aim to connect a blood-clotting protein to the hormone system that drives fluid retention and heart weakening.
Who could benefit from this research
Good fit: Ideal candidates would be people with heart failure with reduced ejection fraction, especially those with dilated cardiomyopathy or evidence of elevated renin activity.
Not a fit: People without heart failure (or with heart failure with preserved ejection fraction) or those whose condition is driven by non-RAAS causes may not benefit from this work.
Why it matters
Potential benefit: If true, this could point to new treatments that block Factor XIIa or its effect on renin to slow or prevent worsening of heart failure.
How similar studies have performed: This is a novel biological link building on recent lab findings about FXIIa and renin activation, so it is early-stage and has not yet been proven in humans.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Gladysheva, Inna P — University of Arizona
- Study coordinator: Gladysheva, Inna P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.