How extracellular purines affect gut bacteria in inflammatory bowel disease
Modulation of Host-Microbe Interactions by Extracellular Purines in the Gastrointestinal Lumen
['FUNDING_CAREER'] · UNIVERSITY OF COLORADO DENVER · NIH-10791768
This study is looking at how a substance called adenosine affects the bacteria in the gut of people with inflammatory bowel disease (IBD), with the hope of finding new ways to help manage their condition and improve their gut health.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-10791768 on ClinicalTrials.gov |
What this research studies
This research investigates the role of extracellular adenosine in the gastrointestinal tract and its impact on gut microbiota, particularly in patients with inflammatory bowel disease (IBD). The study aims to understand how adenosine influences the growth and behavior of gut bacteria, potentially leading to better management of IBD. By examining the molecular mechanisms behind these interactions, the research seeks to identify new therapeutic targets that could help restore a healthy balance of gut bacteria. Patients may benefit from insights that could lead to innovative treatments for IBD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease, including conditions like Crohn's disease and ulcerative colitis.
Not a fit: Patients without a diagnosis of inflammatory bowel disease or those with other gastrointestinal disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve the management of inflammatory bowel disease and enhance patients' quality of life.
How similar studies have performed: Previous research has shown promising results in understanding gut microbiota interactions, suggesting that this approach could yield significant insights into IBD management.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KAO, DANIEL JOSEPH — UNIVERSITY OF COLORADO DENVER
- Study coordinator: KAO, DANIEL JOSEPH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.