How exposure to harmful chemicals during and after pregnancy affects women's metabolism
The Long-term Influence of Persistent Organic Pollutants Exposure During and After Pregnancy on Metabolic Decline in Women After Pregnancies Complicated by Gestational Diabetes
['FUNDING_R01'] · UNIVERSITY OF SOUTHERN CALIFORNIA · NIH-10653028
This study is looking at how being exposed to certain harmful chemicals during pregnancy and after giving birth might affect women's health, especially for those who had gestational diabetes, to see if it could lead to problems like insulin resistance and a higher chance of getting type 2 diabetes later on.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTHERN CALIFORNIA (nih funded) |
| Locations | 1 site (Los Angeles, UNITED STATES) |
| Trial ID | NIH-10653028 on ClinicalTrials.gov |
What this research studies
This research investigates the long-term effects of exposure to persistent organic pollutants (POPs) during pregnancy and the postpartum period on women's metabolic health, particularly focusing on those who have experienced gestational diabetes mellitus (GDM). The study aims to identify how these chemical exposures may lead to insulin resistance and other metabolic issues that increase the risk of developing type 2 diabetes later in life. By examining the combined effects of various POPs, the research seeks to provide a clearer understanding of how these environmental factors contribute to metabolic decline in women after GDM pregnancies.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who have experienced gestational diabetes during their pregnancies.
Not a fit: Patients who have not had gestational diabetes or are not exposed to persistent organic pollutants may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for type 2 diabetes in women who have had gestational diabetes.
How similar studies have performed: While there is growing evidence linking POPs to metabolic issues, this research aims to explore a novel approach by examining the joint effects of multiple pollutants over a long-term period.
Where this research is happening
Los Angeles, UNITED STATES
- UNIVERSITY OF SOUTHERN CALIFORNIA — Los Angeles, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, ZHANGHUA — UNIVERSITY OF SOUTHERN CALIFORNIA
- Study coordinator: CHEN, ZHANGHUA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.