How exposure to certain smells during early development affects brain circuits related to smell.
Official title: Investigating the effects of olfactory critical period odorant exposure on the trace amine-associated receptor4 olfactory circuit
Funded at University of Pittsburgh at Pittsburgh · NIH-10860966 · Data updated 2026-11-12
This study looks at how certain smells during a key growth stage in young mice can affect their brain and behavior, helping us understand how early experiences with scents can shape how they respond to the world around them.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F31DC021353-02 |
| Project ID | NIH-10860966 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would be individuals interested in the effects of sensory experiences on brain development, particularly those with olfactory disorders or related conditions.
✕Less likely to help
Patients who are not affected by olfactory disorders or those who do not have an interest in sensory processing may not receive any benefit from this research.
What this research studies
This research investigates how exposure to specific odorants during a critical developmental period in young mice influences the brain circuits responsible for olfactory processing. By examining the changes in the olfactory bulb and the behavior of mice exposed to these odors, the study aims to understand the lasting effects of early odorant exposure on innate behavioral responses. The methodology includes tracking changes in brain structure and function through advanced imaging techniques and behavioral assessments. The findings could provide insights into how early sensory experiences shape brain development and behavior.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of how early sensory experiences influence brain development and behavior, potentially informing treatments for olfactory disorders.
How similar studies have gone: Other research has shown success in understanding the impact of sensory experiences on brain development, making this study a continuation of established findings.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Gregory, Jordan Duran — University of Pittsburgh at Pittsburgh
- Study coordinator: Gregory, Jordan Duran
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.