How exposure to certain environmental chemicals before conception affects pregnancy outcomes.
The Impact of Maternal and Paternal Preconception Perfluoroalkyl Substance (PFAS) Exposure on Reproductive and Perinatal Outcomes
This study is looking at how certain chemicals found in the environment, called PFAS, might affect pregnancy and fertility for parents-to-be, by checking their levels before they conceive to see if they relate to issues like pregnancy loss or low birth weight.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard School of Public Health NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10793501 on NIH RePORTER |
What this research studies
This research investigates the effects of per- and polyfluoroalkyl substances (PFAS), common environmental pollutants, on reproductive and pregnancy outcomes. By measuring PFAS levels in parents before conception, the study aims to understand how these chemicals may influence fertility, pregnancy loss, preterm birth, and low birth weight. The research will utilize serum samples to assess exposure levels and their potential impact on both maternal and paternal reproductive health. This approach seeks to fill gaps in existing knowledge regarding the effects of PFAS on human health, particularly in relation to newer PFAS compounds.
Who could benefit from this research
Good fit: Ideal candidates for this research include couples planning to conceive who may have been exposed to PFAS through environmental sources.
Not a fit: Patients who are not planning to conceive or who have no known exposure to PFAS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention of adverse reproductive and pregnancy outcomes linked to environmental exposures.
How similar studies have performed: While there have been studies on PFAS exposure and health outcomes, this research focuses specifically on preconception exposure, making it a novel approach.
Where this research is happening
Boston, United States
- Harvard School of Public Health — Boston, United States (Active)
Researchers
- Principal investigator: Mahalingaiah, Shruthi — Harvard School of Public Health
- Study coordinator: Mahalingaiah, Shruthi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.