How exposure to a common pollutant affects gut bacteria and behavior over generations
Impacts of Benzo[a]pyrene on Microbiome Development across Lifespan and Generations and the Behavioral Consequences
This study is looking at how a harmful chemical called benzo[a]pyrene can change the gut bacteria in developing zebrafish, which might lead to problems with behavior and thinking, and it hopes to find ways to help not just the fish but also future generations.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon State University NIH-funded |
| Lab location | 1 site (Corvallis, United States) |
| Project ID | NIH-10549792 on NIH RePORTER |
What this research studies
This research investigates how exposure to the environmental pollutant benzo[a]pyrene during development can change the gut microbiome, which may lead to behavioral and cognitive issues. Using a germ-free animal model, specifically zebrafish, the study will explore the relationship between gut bacteria alterations and behavioral outcomes. The research aims to understand how these changes can affect not only the exposed individuals but also subsequent generations. By identifying specific gut microbes and their metabolites that influence behavior, the study seeks to uncover new avenues for addressing behavioral disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been exposed to environmental pollutants during early development and are experiencing behavioral or cognitive challenges.
Not a fit: Patients who have not been exposed to environmental pollutants or do not exhibit behavioral or cognitive disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating behavioral and cognitive disorders linked to environmental exposures.
How similar studies have performed: Previous research has indicated that environmental toxins can impact gut microbiome development, suggesting that this approach may yield significant insights into behavioral health.
Where this research is happening
Corvallis, United States
- Oregon State University — Corvallis, United States (Active)
Researchers
- Principal investigator: Sharpton, Thomas Jefferson — Oregon State University
- Study coordinator: Sharpton, Thomas Jefferson
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.