How exosomes and the complement system affect organ transplant success
Complement-Mediated Exosome Function in Transplantation
This study is looking at how tiny particles from donor organs can affect the immune system of transplant recipients, especially how they might help or hinder the body from accepting the new organ, with the goal of finding better ways to ensure successful transplants.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10887539 on NIH RePORTER |
What this research studies
This research investigates the role of exosomes and the complement system in the immune response following organ transplantation. It focuses on how these exosomes, which are tiny vesicles released from donor organs, can influence the recipient's immune cells, particularly dendritic cells, to recognize and potentially reject the transplanted organ. The study aims to understand the mechanisms behind this process and how it can be manipulated to improve transplant outcomes. By examining the interactions between complement proteins and exosomes, the researchers hope to identify new strategies to enhance graft survival.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are undergoing or have recently undergone organ transplantation.
Not a fit: Patients who are not candidates for organ transplantation or those with conditions unrelated to transplant rejection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing organ rejection in transplant patients.
How similar studies have performed: Other research has shown promising results in understanding the role of the complement system in transplant rejection, indicating that this approach has potential for success.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Chun, Nicholas — Icahn School of Medicine at Mount Sinai
- Study coordinator: Chun, Nicholas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.