How exercise timing and social jetlag affect heart and metabolic health
Official title: Effects of time-of-day dependent exercise training on social jetlag induced susceptibility to cardiometabolic disease
Funded at University of Nevada Las Vegas · NIH-11135579 · Data updated 2026-11-12
This project looks at whether mismatched weekday/weekend sleep schedules change how the timing of exercise helps protect heart and metabolic health for people at risk of cardiovascular and metabolic problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nevada Las Vegas NIH-funded |
| Lab location | 1 site (Las Vegas, United States) |
| Project start | August 4, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $189,375 |
| NIH project number | 5R16GM150488-03 |
| Project ID | NIH-11135579 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with irregular sleep schedules (for example shift workers or people who change sleep times on weekends) or those at increased risk for cardiometabolic disease.
✕Less likely to help
People with very regular sleep schedules who are not at cardiometabolic risk, and individuals unable to perform regular exercise, are less likely to benefit directly from this work.
What this research studies
You would learn whether chronic differences between weekday and weekend sleep schedules (called social jetlag) reduce the benefits people get from regular exercise. The team will compare exercise performed at different times of day under normal and misaligned sleep schedules and measure fitness, blood markers of metabolism, and heart-related signals. Participants’ sleep and activity patterns will be tracked and fitness tests and blood samples taken across weeks of training. The aim is to find practical timing advice that helps exercise protect the heart and metabolism when daily schedules are irregular.
Why it matters
Potential benefit: If successful, this work could lead to simple exercise-timing recommendations that better protect against heart disease and metabolic problems for people with irregular schedules.
How similar studies have gone: Prior animal and some human studies show time-of-day can change exercise effects, but studying the impact of chronic social jetlag on exercise training responses is a new application.
Where this research is happening
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University of Nevada Las Vegas
Las Vegas, United States Active
Researchers
- Principal investigator: Mcginnis, Graham Ripley — University of Nevada Las Vegas
- Study coordinator: Mcginnis, Graham Ripley
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.