How exercise helps protect the heart from damage
Skeletal Muscle Nrf2: Exercise-Induced Cardiovascular Protection
['FUNDING_R01'] · UNIVERSITY OF NEBRASKA MEDICAL CENTER · NIH-10994635
This study is looking at how exercise can help keep your heart healthy, especially if you have chronic heart failure or have recently had a heart issue, by exploring how certain helpful proteins from your muscles can protect your heart from damage.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEBRASKA MEDICAL CENTER (nih funded) |
| Locations | 1 site (OMAHA, UNITED STATES) |
| Trial ID | NIH-10994635 on ClinicalTrials.gov |
What this research studies
This research investigates how exercise training can help protect the heart, particularly in patients with chronic heart failure and those experiencing acute coronary events. It focuses on the role of antioxidant enzymes produced in skeletal muscle, which may be transferred to other organs to enhance their protective effects. By studying specific mouse models, the researchers aim to understand how these antioxidants can improve heart function and reduce damage from ischemia. The findings could lead to new strategies for using exercise as a therapeutic intervention for heart conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with chronic heart failure or those who have experienced acute coronary ischemia.
Not a fit: Patients with stable heart conditions who do not engage in exercise or have no history of heart failure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved heart health and recovery strategies for patients with heart failure and those at risk of heart attacks.
How similar studies have performed: Previous research has shown promising results in using exercise to enhance heart protection, suggesting that this approach may be effective.
Where this research is happening
OMAHA, UNITED STATES
- UNIVERSITY OF NEBRASKA MEDICAL CENTER — OMAHA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GAO, LIE — UNIVERSITY OF NEBRASKA MEDICAL CENTER
- Study coordinator: GAO, LIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.