How exercise affects muscle metabolism through reactive oxygen species
Official title: Endothelial Reactive Oxygen Species in Exercise Metabolism
Funded at Virginia Polytechnic Inst and St Univ · NIH-11175783 · Data updated 2026-11-12
This study is looking at how exercise affects muscle metabolism and whether certain molecules in the body, called reactive oxygen species, help or hurt our muscles during workouts, which could lead to better ways to stay healthy and prevent muscle-related diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Polytechnic Inst and St Univ NIH-funded |
| Lab location | 1 site (Blacksburg, United States) |
| Project start | September 20, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $354,200 |
| NIH project number | 1R56AR083948-01 |
| Project ID | NIH-11175783 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals interested in improving their muscle metabolism through exercise, particularly those at risk for metabolic diseases.
✕Less likely to help
Patients who are unable to engage in physical activity or have severe metabolic disorders may not benefit from this research.
What this research studies
This research investigates how exercise influences the metabolism of skeletal muscle by examining the role of reactive oxygen species (ROS). It aims to understand the complex signaling processes that occur in muscle cells during exercise, including communication between different cell types such as myocytes and endothelial cells. By focusing on the enzyme NADPH oxidase 4 (NOX4), the study seeks to clarify whether ROS are beneficial or harmful in the context of exercise-induced muscle adaptation. The findings could lead to new strategies for promoting health and preventing diseases related to muscle metabolism.
Why it matters
Potential benefit: If successful, this research could lead to improved exercise strategies that enhance muscle health and prevent diseases like diabetes.
How similar studies have gone: Previous research has shown that understanding the role of ROS in muscle metabolism can lead to significant advancements in exercise science, indicating that this approach has potential for success.
Where this research is happening
-
Virginia Polytechnic Inst and St Univ
Blacksburg, United States Active
Researchers
- Principal investigator: Craige, Siobhan M — Virginia Polytechnic Inst and St Univ
- Study coordinator: Craige, Siobhan M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.