How exercise affects heart failure and inflammation in the nervous system
Official title: Neural Inflammation and Exercise Pressor Reflex in Heart Failure
Funded at University of Nebraska Medical Center · NIH-10908449 · Data updated 2026-11-12
This study is looking at how inflammation in the brain affects the way people with chronic heart failure respond to exercise, with the goal of finding better ways to help them manage their symptoms and improve their ability to be active.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | August 16, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $615,663 |
| NIH project number | 5R01HL169205-02 |
| Project ID | NIH-10908449 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic heart failure who experience exercise intolerance.
✕Less likely to help
Patients without chronic heart failure or those who do not experience exercise-related complications may not benefit from this research.
What this research studies
This research investigates the relationship between neural inflammation and the exercise pressor reflex in patients with chronic heart failure (CHF). It focuses on how the sympathetic nervous system responds during physical activity, particularly the exaggerated pressor response that can increase cardiovascular risks. By examining the mechanisms behind this response, including the role of macrophages in lumbar dorsal root ganglia, the study aims to uncover new insights into how exercise intolerance in CHF patients can be better understood and potentially managed.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing exercise-related risks in heart failure patients, enhancing their quality of life.
How similar studies have gone: Previous research has shown that understanding the mechanisms of sympathetic nervous system activation during exercise can lead to significant advancements in managing heart failure, suggesting this approach has potential for success.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Wang, Hanjun — University of Nebraska Medical Center
- Study coordinator: Wang, Hanjun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.