How exercise affects gut bacteria and immune response in melanoma treatment
Role of physical exercise-induced microbiota changes in immunotherapy resistant preclinical melanoma
This study is looking at how physical exercise might change the bacteria in your gut and help make immunotherapy for melanoma work better, especially for patients who haven't had success with other treatments.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11066790 on NIH RePORTER |
What this research studies
This research investigates the impact of physical exercise on gut microbiota and its potential role in enhancing the effectiveness of immunotherapy for melanoma. By using preclinical models, the study aims to understand how exercise-induced changes in gut bacteria can influence immune responses, particularly the activity of CD8 T cells, which are crucial for fighting tumors. The researchers will explore the mechanisms behind these changes and their implications for improving treatment outcomes for melanoma patients resistant to current therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are melanoma patients who are currently undergoing or considering immunotherapy treatments.
Not a fit: Patients who are not diagnosed with melanoma or those who are not receiving immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing the effectiveness of immunotherapy in melanoma patients through exercise.
How similar studies have performed: While the specific approach of linking exercise, gut microbiota, and immunotherapy in melanoma is novel, previous studies have shown that exercise can improve cancer treatment outcomes.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Phelps, Catherine — University of Pittsburgh at Pittsburgh
- Study coordinator: Phelps, Catherine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.