How exercise affects fat tissue and metabolism during weight loss and regain in obesity
Official title: Exercise effects on adipose tissue morphology, metabolic function, and metabolic health with weight loss and weight regain in obesity
Funded at University of Michigan at Ann Arbor · NIH-11095886 · Data updated 2026-11-12
This study is looking at how exercising and eating less can help people with obesity improve their body fat and overall health, so if you're interested in how these changes can affect your weight and metabolism, this research might be for you!
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | August 16, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $625,822 |
| NIH project number | 5R01DK131724-04 |
| Project ID | NIH-11095886 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with obesity who are looking to lose weight and improve their metabolic health.
✕Less likely to help
Patients who are not overweight or obese may not receive benefit from this research.
What this research studies
This research investigates the combined effects of exercise and caloric restriction on fat tissue and metabolic health in individuals with obesity. It aims to understand how exercise influences the structure and function of adipose tissue, particularly in relation to weight loss and regain. By exploring the mechanisms behind these changes, the study seeks to optimize lifestyle interventions for better health outcomes. Participants may engage in exercise programs while undergoing dietary changes to assess the impacts on their body fat and metabolic function.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing obesity and its related health complications.
How similar studies have gone: Previous research has shown promising results regarding the benefits of combining exercise with caloric restriction for weight management and metabolic health.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Horowitz, Jeffrey F — University of Michigan at Ann Arbor
- Study coordinator: Horowitz, Jeffrey F
Related research
Other NIH-funded projects on the same topics.
-
Exercise and fat tissue: how workouts change fat tissue and metabolic health during weight loss and regain
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-
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-
Adding yoga to a weight-loss program for adults with overweight or obesity
This trial compares whether adding regular yoga to a standard behavioral weight-loss program helps adults with overweight or obesity lose more weight over 12 months.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.