How exercise affects cell communication in muscle metabolism
Official title: Endothelial Signaling in Exercise Metabolism
Funded at Virginia Polytechnic Inst and St Univ · NIH-10793119 · Data updated 2026-11-12
This study is looking at how different cells in your muscles talk to each other during exercise to help produce energy, and it aims to find ways to improve muscle health and prevent related diseases.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Polytechnic Inst and St Univ NIH-funded |
| Lab location | 1 site (Blacksburg, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $72,753 |
| NIH project number | 1R03AR083493-01 |
| Project ID | NIH-10793119 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in understanding how exercise impacts muscle health and metabolism.
✕Less likely to help
Patients who are unable to engage in exercise or have severe mobility limitations may not benefit from this research.
What this research studies
This research investigates the complex signaling processes that occur in skeletal muscle during exercise, focusing on how different cell types communicate to enhance energy production. By studying the role of reactive oxygen species and a specific enzyme called NADPH oxidase 4, which is primarily found in vascular endothelial cells, the research aims to uncover the mechanisms that drive metabolic responses to exercise. Understanding these pathways could lead to new strategies for promoting health and preventing diseases related to muscle metabolism.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing muscle metabolism and preventing related diseases through exercise.
How similar studies have gone: Previous research has shown promising results in understanding the role of cell signaling in exercise metabolism, indicating that this approach has potential for significant findings.
Where this research is happening
-
Virginia Polytechnic Inst and St Univ
Blacksburg, United States Active
Researchers
- Principal investigator: Craige, Siobhan M — Virginia Polytechnic Inst and St Univ
- Study coordinator: Craige, Siobhan M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.