How exercise affects brain activity in Parkinson's disease
The impact of exercise on subthalamic nucleus neural activity in Parkinson's disease
This study is looking at how riding a stationary bike can help improve movement and brain activity in people with Parkinson's disease, to see if exercise can make a positive difference in their daily lives.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10677893 on NIH RePORTER |
What this research studies
This research investigates the effects of aerobic exercise, particularly stationary cycling, on brain activity in individuals with Parkinson's disease. It aims to understand how forced exercise can improve motor function by examining neural activity in the basal ganglia, a brain region affected by the disease. The study will utilize advanced techniques to measure changes in neural synchronization associated with exercise, providing insights into how physical activity may modify the disease's progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease who are capable of participating in aerobic exercise programs.
Not a fit: Patients with advanced Parkinson's disease who are unable to engage in physical activity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved exercise recommendations that enhance motor function and quality of life for patients with Parkinson's disease.
How similar studies have performed: Previous studies have shown promising results with forced exercise in animal models and initial human trials, indicating potential for success in this approach.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Alberts, Jay L. — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Alberts, Jay L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.