How exercise affects blood vessel health as we age
Official title: Exerkines and the heterogeneity of peripheral and cerebral vascular adaptations to exercise training with aging in women and men
Funded at University of Colorado Denver · NIH-10978109 · Data updated 2026-11-12
This study is looking at how regular aerobic exercise can help keep blood vessels healthy as we get older, and it’s for both younger and older adults, including men and women, who will take part in a 12-week exercise program to see how their vascular health changes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | August 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $1,580,676 |
| NIH project number | 1R01AG089069-01 |
| Project ID | NIH-10978109 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include healthy adults aged 18 and older, particularly those interested in understanding how exercise can benefit their vascular health.
✕Less likely to help
Patients with severe cardiovascular conditions or those unable to participate in aerobic exercise may not benefit from this research.
What this research studies
This research investigates how regular aerobic exercise influences the health of blood vessels in the brain and body as people age. It focuses on understanding the differences in response to exercise between younger and older adults, as well as between men and women. Participants will engage in a 12-week aerobic exercise program, with assessments of their vascular health before and after the intervention. The study aims to uncover the biological factors that contribute to variations in vascular health improvements from exercise.
Why it matters
Potential benefit: If successful, this research could lead to improved exercise recommendations that enhance vascular health and reduce the risk of cardiovascular diseases and Alzheimer's disease in older adults.
How similar studies have gone: Previous research has shown that aerobic exercise can positively impact vascular health, making this study a continuation of established findings with a focus on age and sex differences.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Moreau, Kerrie — University of Colorado Denver
- Study coordinator: Moreau, Kerrie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.