How ETS-family genes control lung inflammation during influenza
ETS-family Transcription Factor Mediated Control of Pulmonary Inflammation Induced by Influenza Viruses
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-11224055
This project looks at whether a gene called ETV7 helps switch off harmful lung inflammation after the flu to protect people who get influenza.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11224055 on ClinicalTrials.gov |
What this research studies
Researchers are studying a gene (ETV7) that may help stop prolonged interferon-driven inflammation in the lungs after influenza infection. They use genome-wide CRISPR activation screens, lab-grown respiratory cells, and animal models to find and test regulators of interferon signaling. The team will change ETV7 activity to see how that affects lung inflammation, infected cell survival, and tissue healing. Findings could point toward new ways to limit damaging inflammation while preserving antiviral defenses.
Who could benefit from this research
Good fit: People who have recently had influenza, experienced severe flu-related lung inflammation, or are willing to provide respiratory samples would be most relevant to this research.
Not a fit: People without influenza-related lung inflammation or those seeking immediate clinical treatments may not receive direct benefits from this basic research.
Why it matters
Potential benefit: If successful, this work could lead to treatments that reduce harmful lung inflammation from influenza and help the lungs recover faster.
How similar studies have performed: Lab studies have begun to identify ETV7 as a regulator of interferon signaling, but translating this finding into therapies is still new and early-stage.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HEATON, NICHOLAS S — DUKE UNIVERSITY
- Study coordinator: HEATON, NICHOLAS S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.