How estrogen receptor alpha affects heart cell metabolism and health
The impact of estrogen receptor alpha on cardiomyocellular metabolism and health
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-10919844
This study is looking at how a hormone called estrogen affects heart health, especially for women going through menopause, by using special mice to see how changes in estrogen receptors in heart cells might lead to heart problems, with the hope of finding better treatments for those at risk.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10919844 on ClinicalTrials.gov |
What this research studies
This research investigates the role of estrogen receptor alpha (ERα) in heart cell metabolism and overall heart health, particularly during the menopausal transition. It focuses on understanding how changes in ERα levels can lead to cardiometabolic diseases, such as heart failure, by using genetically modified mice to observe the effects of ERα manipulation in heart cells. The study aims to clarify the specific mechanisms by which ERα influences heart function and metabolism, which could lead to targeted therapies for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing menopausal symptoms or those with a history of cardiometabolic diseases.
Not a fit: Patients who are not experiencing hormonal changes or do not have a history of heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart health and reduce the risk of heart failure in individuals affected by estrogen-related changes.
How similar studies have performed: Previous research has shown promising results in understanding the role of estrogen in heart health, indicating that this approach could yield valuable insights.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HEVENER, ANDREA L — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: HEVENER, ANDREA L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Anti-Cancer Agents