How estrogen may protect against colorectal cancer in obese individuals
Official title: Estrogenic protection against colorectal cancer development in obesity
Funded at Miami University Oxford · NIH-10730681 · Data updated 2026-11-12
This study is looking at how obesity and estrogen might work together to affect the risk of developing colorectal cancer, and it's for anyone interested in understanding how these factors could help in finding new ways to prevent this type of cancer.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Miami University Oxford NIH-funded |
| Lab location | 1 site (Oxford, United States) |
| Project start | July 19, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2023 |
| Award (this year) | $433,500 |
| NIH project number | 1R15CA274480-01A1 |
| Project ID | NIH-10730681 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are obese individuals, particularly premenopausal women, who are at risk for sporadic colorectal cancer.
✕Less likely to help
Patients who are not obese or those with a strong family history of colorectal cancer may not benefit from this research.
What this research studies
This research investigates the relationship between obesity, estrogen, and the development of sporadic colorectal cancer (CRC). It aims to understand how estrogen may counteract the inflammatory factors associated with obesity that contribute to CRC risk. By exploring the interactions between adipokines, cytokines, and estrogen, the study seeks to uncover mechanisms that could lead to new prevention strategies. The research will utilize animal models to simulate the early stages of obesity-related CRC.
Why it matters
Potential benefit: If successful, this research could lead to new preventive measures or treatments for colorectal cancer in obese patients.
How similar studies have gone: While the interactions between estrogen and obesity-related factors in CRC are not extensively studied, similar research has shown promising results in understanding cancer mechanisms.
Where this research is happening
-
Miami University Oxford
Oxford, United States Active
Researchers
- Principal investigator: Shi, Haifei — Miami University Oxford
- Study coordinator: Shi, Haifei
Related research
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-
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This study is looking at whether eating all your meals within a set time each day can help adults with obesity lose weight and improve health markers related to colorectal cancer risk, compared to just cutting calories throughout the day.
-
Comparing time-restricted eating and continuous calorie restriction for weight loss and colorectal cancer risk in obese adults
This study is looking at how two different eating plans—one where you eat all your meals in a set time each day and another where you simply eat fewer calories throughout the day—can help adults with obesity lose weight and lower their risk of colorectal cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.