How estrogen affects temperature control in the brain
Estrogenic modulation of neural circuits that control temperature
This study is looking at how the drop in estrogen during menopause affects the brain's ability to control body temperature, helping us understand why some women experience temperature-related symptoms during this time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10885917 on NIH RePORTER |
What this research studies
This research investigates the impact of estrogen withdrawal during menopause on temperature regulation in the brain. It focuses on understanding how estrogen receptor alpha (ERalpha) neurons in the medial preoptic area of the hypothalamus influence thermoregulation. The study aims to define the role of these neurons, explore the neural circuits involved, and examine the genetic effects of estrogen signaling. By using advanced techniques, the research seeks to uncover the mechanisms behind temperature-related symptoms experienced during menopause.
Who could benefit from this research
Good fit: Ideal candidates for this research are postmenopausal women experiencing vasomotor symptoms.
Not a fit: Patients who are premenopausal or do not experience menopausal symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new non-hormonal therapies for managing menopausal symptoms like hot flashes and night sweats.
How similar studies have performed: Other research has shown promising results in understanding hormonal influences on temperature regulation, making this approach both relevant and potentially impactful.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Correa, Stephanie — University of California Los Angeles
- Study coordinator: Correa, Stephanie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.