How estrogen affects memory and brain structure
Estrogenic regulation of the hippocampal ubiquitin-proteasome system and its role in memory and structural plastcity
['FUNDING_R01'] · UNIVERSITY OF WISCONSIN MILWAUKEE · NIH-11083164
This study is looking at how the hormone 17β-estradiol affects memory and brain changes, helping us understand how it might influence thinking and learning in both men and women.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN MILWAUKEE (nih funded) |
| Locations | 1 site (MILWAUKEE, UNITED STATES) |
| Trial ID | NIH-11083164 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the hormone 17β-estradiol in regulating memory formation and brain plasticity, particularly in the hippocampus. It aims to understand how this hormone influences the ubiquitin-proteasome system, which is crucial for protein degradation and synaptic remodeling. By studying both males and females, the research seeks to uncover the neural mechanisms that link estrogen to memory consolidation and changes in brain structure. Patients may benefit from insights into how hormonal changes affect memory and cognitive function.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older, particularly those experiencing memory issues or neuropsychiatric conditions.
Not a fit: Patients who are under 21 years old or do not have memory-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for memory impairments associated with neuropsychiatric disorders.
How similar studies have performed: Previous research has shown that hormonal regulation of memory and brain plasticity is a promising area, but the specific mechanisms being explored in this study are relatively novel.
Where this research is happening
MILWAUKEE, UNITED STATES
- UNIVERSITY OF WISCONSIN MILWAUKEE — MILWAUKEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FRICK, KARYN M — UNIVERSITY OF WISCONSIN MILWAUKEE
- Study coordinator: FRICK, KARYN M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.