How estrogen affects lung inflammation caused by ozone exposure
Official title: Estrogen receptor signaling, inflammation and ozone toxicity
Funded at University of Connecticut Storrs · NIH-11082284 · Data updated 2026-11-12
This study looks at how certain immune cells in the lungs react to ozone and how estrogen affects this reaction, with the goal of finding better treatments for lung problems caused by ozone, especially for kids and older adults.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Storrs NIH-funded |
| Lab location | 1 site (Storrs-Mansfield, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $247,765 |
| NIH project number | 5R00ES032473-05 |
| Project ID | NIH-11082284 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children under 11 years old and older adults who are exposed to high levels of air pollution.
✕Less likely to help
Patients with conditions unrelated to lung inflammation or those not exposed to ozone pollution may not benefit from this research.
What this research studies
This research investigates how different types of immune cells in the lungs, specifically macrophages, respond to ozone exposure and how estrogen influences this response. It focuses on understanding the balance between pro-inflammatory and anti-inflammatory macrophages, which is crucial for resolving lung inflammation. By examining the metabolic processes involved in these immune responses, the study aims to uncover mechanisms that could lead to better treatments for ozone-related lung issues, particularly in vulnerable populations like children and the elderly.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing lung inflammation and protecting against ozone toxicity, particularly for sensitive groups.
How similar studies have gone: Other research has shown promising results in understanding the role of immune responses in lung inflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Connecticut Storrs
Storrs-Mansfield, United States Active
Researchers
- Principal investigator: Smith, Ley C — University of Connecticut Storrs
- Study coordinator: Smith, Ley C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.