How estrogen affects inflammation in the brain during HIV infection and PTSD.
Estrogen regulation of age and PTSD-associated changes in macrophage-induced neuroinflammation during HIV infection.
['FUNDING_CAREER'] · SPELMAN COLLEGE · NIH-10913451
This study is looking at how estrogen might help reduce brain inflammation caused by certain immune cells in women with HIV and PTSD, especially after menopause, to find better treatment options for these conditions.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SPELMAN COLLEGE (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-10913451 on ClinicalTrials.gov |
What this research studies
This research investigates the role of estrogen in regulating neuroinflammation caused by macrophages and microglia in individuals living with HIV and PTSD. It focuses on understanding how changes in estrogen levels, particularly in postmenopausal women, may influence the progression of neurological disorders associated with HIV. By exploring the signaling mechanisms of estrogen, the study aims to identify potential therapeutic targets that could lead to more effective treatments for these conditions. The research employs in vitro models to analyze the effects of estrogen on neuroinflammatory processes.
Who could benefit from this research
Good fit: Ideal candidates for this research include postmenopausal women who are living with HIV and experiencing PTSD-related symptoms.
Not a fit: Patients who are not postmenopausal or those without HIV or PTSD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve neurological health and quality of life for individuals living with HIV and PTSD.
How similar studies have performed: Previous research has shown that estrogen has neuroprotective effects, suggesting that this approach may hold promise for addressing neuroinflammation in similar contexts.
Where this research is happening
ATLANTA, UNITED STATES
- SPELMAN COLLEGE — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WILLIAMS, KIMBERLY S. — SPELMAN COLLEGE
- Study coordinator: WILLIAMS, KIMBERLY S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus