How estrogen affects immune responses in inflammatory bowel disease
Estrogen-mediated immune regulation in human and experimental inflammatory bowel disease
This study is looking at how estrogen affects the immune system in people with inflammatory bowel disease (IBD) and hopes to find ways to use this knowledge to help manage inflammation and improve treatment options for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11056064 on NIH RePORTER |
What this research studies
This research investigates the role of estrogen in regulating immune responses in patients with inflammatory bowel disease (IBD). It focuses on how estrogen signaling influences the function of regulatory T cells, which are crucial for controlling inflammation in the intestines. By examining tissue samples and using experimental models, the study aims to understand the mechanisms by which estrogen can either promote or inhibit inflammation in IBD. The findings could lead to new therapeutic strategies that harness estrogen's effects to improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease, particularly those experiencing active symptoms.
Not a fit: Patients with inflammatory bowel disease who are in remission or those without a diagnosis of IBD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage inflammation in patients with inflammatory bowel disease.
How similar studies have performed: Previous research has shown promising results regarding the role of estrogen in immune regulation, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Goodman, Wendy Ann — Case Western Reserve University
- Study coordinator: Goodman, Wendy Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.