How estrogen affects hydration in vocal folds
Estrogenic regulation of systemic vocal fold dehydration
This study looks at how estrogen affects hydration in the body and how that might impact the vocal cords, using rats to see what happens when they are dehydrated and how their voices change.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project ID | NIH-11061248 on NIH RePORTER |
What this research studies
This research investigates the role of estrogen in regulating hydration balance in the body, specifically focusing on how systemic dehydration affects vocal fold tissues. Using a rat model, the study manipulates hormonal and hydration states to observe changes in tissue biology, blood flow, and vocalization outcomes. By examining both male and female rats, the research aims to understand the biological impacts of estrogen on vocal fold hydration and its potential consequences for vocal health.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be individuals experiencing voice disorders related to hydration issues, particularly those affected by hormonal changes.
Not a fit: Patients who do not have voice disorders or those whose conditions are unrelated to hydration or hormonal factors may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of vocal fold dehydration, potentially benefiting individuals with voice disorders.
How similar studies have performed: While the specific approach of this research may be novel, studies on the effects of estrogen on hydration and tissue biology have shown promising results in related fields.
Where this research is happening
West Lafayette, United States
- Purdue University — West Lafayette, United States (Active)
Researchers
- Principal investigator: Sivasankar, Preeti M. — Purdue University
- Study coordinator: Sivasankar, Preeti M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.