How estrogen affects heart rhythm problems
Official title: The Effects of Estrogen on Cardiac Arrhythmic Propensity
Funded at Emory University · NIH-11030231 · Data updated 2026-11-12
This study is looking at how estrogen might help protect the hearts of people with long QT syndrome from dangerous rhythm problems, especially during pregnancy, to find better treatments that consider differences between men and women.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | February 10, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $248,345 |
| NIH project number | 5R00HL143211-05 |
| Project ID | NIH-11030231 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include women with long QT syndrome, especially those who are pregnant or planning to become pregnant.
✕Less likely to help
Patients with cardiac arrhythmias not related to hormonal influences or those who are not female may not benefit from this research.
What this research studies
This research investigates the role of estrogen in influencing heart rhythm issues, particularly in patients with long QT syndrome who are at risk for serious cardiac arrhythmias. The project aims to understand how elevated estrogen levels during pregnancy may provide protective effects against these arrhythmias. By utilizing advanced techniques in stem cell biology and electrophysiology, the research will explore the mechanisms by which estrogen interacts with heart cells. The findings could lead to new insights into sex-specific treatments for heart conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with cardiac arrhythmias, particularly those affected by hormonal changes.
How similar studies have gone: Previous research has shown promising results in understanding the effects of sex hormones on cardiovascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Itzhaki, Ilanit — Emory University
- Study coordinator: Itzhaki, Ilanit
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.