How estrogen affects brain tumors and their spread
Mechanisms underlying pro-metastatic effects of estrogen in the brain niche
This study is looking at how the hormone estrogen might help certain brain tumors grow and spread, especially in cases where the tumors don't have estrogen receptors, to find new ways to prevent or treat these types of cancer.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10841398 on NIH RePORTER |
What this research studies
This research investigates the role of estrogen, specifically estradiol, in promoting the growth and spread of certain types of brain tumors. It focuses on understanding how estrogen influences the brain's microenvironment and the behavior of cancer cells, particularly in estrogen-receptor negative tumors. By studying the interactions between estrogen and brain cells, the research aims to uncover new strategies for preventing or treating brain metastases. Patients may benefit from insights that could lead to novel therapies targeting these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with estrogen-receptor negative brain tumors or those at risk of developing such tumors.
Not a fit: Patients with estrogen-receptor positive tumors may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce the spread of brain tumors influenced by estrogen.
How similar studies have performed: Other research has shown promising results in understanding the role of hormones in cancer progression, suggesting that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Cittelly, Diana M. — University of Colorado Denver
- Study coordinator: Cittelly, Diana M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.