How Estrogen Affects Brain Signals for Ovulation
Central Actions of Estrogens: Effects on GnRH Neurons
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11093529
This work helps us understand how the brain uses estrogen to control ovulation and how stress can disrupt this process, which is important for couples facing infertility.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11093529 on ClinicalTrials.gov |
What this research studies
Many couples experience difficulty conceiving, and understanding how ovulation is controlled is key to helping patients with infertility. This project looks at how the brain responds to estrogen from the ovaries to create the signal that leads to ovulation. We also explore how stress can interfere with this delicate balance. By studying these brain signals, we hope to learn more about the fundamental processes of reproduction.
Who could benefit from this research
Good fit: This foundational research is relevant to adult women experiencing infertility or those interested in the basic science of reproductive health.
Not a fit: Patients seeking immediate clinical treatments or direct participation in a human clinical trial would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of female reproductive health, potentially improving treatments for infertility and managing the effects of stress on ovulation.
How similar studies have performed: This work builds upon previous findings that show how cyclical changes in estrogen affect brain neurons involved in ovulation.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MOENTER, SUZANNE M — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: MOENTER, SUZANNE M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.