How Estrogen Affects Blood Vessels in the Uterus
Actions of Estrogen on Uterine Artery Endothelium
This work explores how a natural substance called hydrogen sulfide helps estrogen increase blood flow to the uterus during pregnancy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11089343 on NIH RePORTER |
What this research studies
Our bodies naturally produce hydrogen sulfide, which helps blood vessels in the uterus relax and expand. This is especially important during pregnancy when more blood flow is needed to support the baby. We are learning how estrogen, a key hormone, uses hydrogen sulfide to increase blood flow and how this process might be different in conditions like preeclampsia. Understanding these natural processes could help us find new ways to support healthy pregnancies and address complications.
Who could benefit from this research
Good fit: This research is relevant for pregnant individuals, especially those experiencing or at risk for conditions like preeclampsia.
Not a fit: Patients not experiencing pregnancy-related cardiovascular issues may not directly benefit from this specific research.
Why it matters
Potential benefit: This work could lead to new ways to manage blood flow issues during pregnancy, potentially helping those with conditions like preeclampsia.
How similar studies have performed: Previous work has established hydrogen sulfide as a uterine artery dilator, and this research builds upon those findings to explore its specific mechanisms.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Chen, Dongbao — University of California-Irvine
- Study coordinator: Chen, Dongbao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.