How essential genes influence aging
Understanding of Essential Gene Function in Aging
['FUNDING_R01'] · UNIVERSITY OF VIRGINIA · NIH-11301031
Researchers will examine core genes found in yeast and worms to learn which ones change lifespan and could matter for human aging.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-11301031 on ClinicalTrials.gov |
What this research studies
This project uses high-throughput genetic approaches in yeast and the worm C. elegans to switch off or reduce essential genes and observe effects on lifespan. The team focuses on genes that are conserved across species, especially those with human equivalents, to find signals that repeat in multicellular animals. Work combines systematic gene knockouts in yeast and RNA interference in worms to identify candidates that alter aging. Findings will point to genes worth testing later in mammalian systems and, eventually, in human-focused research.
Who could benefit from this research
Good fit: People concerned about aging or age-related conditions could be future beneficiaries of therapies developed from these findings, although they would not join the lab work itself.
Not a fit: Patients seeking immediate treatments are unlikely to benefit now because the work is basic laboratory research in model organisms.
Why it matters
Potential benefit: If successful, this work could reveal fundamental genes that control aging and point to new targets for therapies to delay age-related decline.
How similar studies have performed: Previous studies in yeast and worms have identified genes that affect lifespan, but a comprehensive focus on conserved essential genes across species is new.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KAYA, ALAATTIN — UNIVERSITY OF VIRGINIA
- Study coordinator: KAYA, ALAATTIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Candidate Disease Gene