How Epstein-Barr Virus contributes to certain lymphomas in AIDS patients
Stringent Latent Epstein-Barr Virus (EBV) Infection Collaborates with Cellular Gene Alterations to Induce EBV+ Lymphomas
This study is looking at how a virus called Epstein-Barr Virus (EBV) might cause certain types of lymphomas in people with AIDS, using special lab techniques to find out how a specific version of the virus can still lead to these cancers, with the hope of discovering better treatments for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10837753 on NIH RePORTER |
What this research studies
This research investigates the role of Epstein-Barr Virus (EBV) in the development of specific types of lymphomas, particularly in patients with AIDS. The study utilizes a novel in vitro cell culture model and a specialized mouse model to explore how a specific mutant of EBV, which lacks a key protein, can still induce lymphoma-like conditions. By understanding the mechanisms behind EBV's influence on B cells and lymphoma development, the research aims to uncover new insights into treatment options for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with AIDS who are at risk for developing EBV-associated lymphomas.
Not a fit: Patients who do not have AIDS or EBV-related lymphomas may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for lymphomas associated with EBV in AIDS patients.
How similar studies have performed: Previous research has shown that understanding viral mechanisms in lymphoma development can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Kenney, Shannon Celeste — University of Wisconsin-Madison
- Study coordinator: Kenney, Shannon Celeste
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.