How Epstein-Barr Virus contributes to certain lymphomas in AIDS patients
Official title: Stringent Latent Epstein-Barr Virus (EBV) Infection Collaborates with Cellular Gene Alterations to Induce EBV+ Lymphomas
Funded at University of Wisconsin-Madison · NIH-10837753 · Data updated 2026-11-12
This study is looking at how a virus called Epstein-Barr Virus (EBV) might cause certain types of lymphomas in people with AIDS, using special lab techniques to find out how a specific version of the virus can still lead to these cancers, with the hope of discovering better treatments for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $406,157 |
| NIH project number | 5R01CA281379-02 |
| Project ID | NIH-10837753 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with AIDS who are at risk for developing EBV-associated lymphomas.
✕Less likely to help
Patients who do not have AIDS or EBV-related lymphomas may not benefit from this research.
What this research studies
This research investigates the role of Epstein-Barr Virus (EBV) in the development of specific types of lymphomas, particularly in patients with AIDS. The study utilizes a novel in vitro cell culture model and a specialized mouse model to explore how a specific mutant of EBV, which lacks a key protein, can still induce lymphoma-like conditions. By understanding the mechanisms behind EBV's influence on B cells and lymphoma development, the research aims to uncover new insights into treatment options for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for lymphomas associated with EBV in AIDS patients.
How similar studies have gone: Previous research has shown that understanding viral mechanisms in lymphoma development can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Kenney, Shannon Celeste — University of Wisconsin-Madison
- Study coordinator: Kenney, Shannon Celeste
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.