How Epstein-Barr Virus affects cell recycling processes
Official title: Molecular mechanism by which Epstein-Barr Virus-encoded BHRF1 blocks BECN1-mediated autophagy
Funded at North Dakota State University · NIH-10439285 · Data updated 2026-11-12
This study is looking at how the Epstein-Barr Virus (EBV) affects a process in our cells that helps get rid of waste, which could lead to new treatments for diseases linked to EBV, like certain cancers and heart problems.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Dakota State University NIH-funded |
| Lab location | 1 site (Fargo, United States) |
| Project start | September 1, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $435,000 |
| NIH project number | 1R15GM146232-01 |
| Project ID | NIH-10439285 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults who have been diagnosed with EBV-related conditions, such as certain cancers or cardiovascular diseases.
✕Less likely to help
Patients who do not have any EBV-related diseases or conditions may not benefit from this research.
What this research studies
This research investigates the role of the Epstein-Barr Virus (EBV) in blocking a cellular process called autophagy, which is essential for degrading unnecessary or harmful cellular components. The study focuses on a specific protein, BECN1, that regulates autophagy and how EBV interacts with this protein to influence cellular health. By understanding these mechanisms, the research aims to uncover potential therapeutic targets for diseases associated with EBV, including various cancers and cardiovascular diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases linked to EBV by restoring proper autophagy function.
How similar studies have gone: Other research has shown promising results in understanding viral interactions with autophagy, suggesting that this approach could yield valuable insights.
Where this research is happening
-
North Dakota State University
Fargo, United States Active
Researchers
- Principal investigator: Hershberger, John F — North Dakota State University
- Study coordinator: Hershberger, John F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.