How EpoR and Stat5 control the growth of red blood cells
Official title: EpoR & Stat5 regulation of ribosome biogenesis and protein synthesis in erythropoiesis
Funded at Univ of Massachusetts Med Sch Worcester · NIH-11045732 · Data updated 2026-11-12
This study is looking at how certain proteins help in making red blood cells by understanding their growth and development, which could lead to better ways to support people with blood-related conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | May 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $463,690 |
| NIH project number | 5R01DK136321-03 |
| Project ID | NIH-11045732 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with disorders affecting red blood cell production or those interested in understanding erythropoiesis.
✕Less likely to help
Patients with conditions unrelated to red blood cell formation may not benefit from this research.
What this research studies
This research investigates the roles of EpoR and Stat5 in regulating the processes of ribosome biogenesis and protein synthesis, which are crucial for the development of red blood cells. By examining how these proteins influence the growth and maturation of erythroblasts, the study aims to uncover new insights into blood cell formation. The researchers utilize advanced techniques such as single-cell RNA sequencing to analyze gene expression changes in specific cell types. This work could lead to a better understanding of how red blood cells are produced and how their development can be optimized.
Why it matters
Potential benefit: If successful, this research could improve treatments for conditions related to red blood cell production, such as anemia.
How similar studies have gone: Previous research has shown promising results in understanding the regulation of erythropoiesis, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Univ of Massachusetts Med Sch Worcester
Worcester, United States Active
Researchers
- Principal investigator: Socolovsky, Merav — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Socolovsky, Merav
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.