How epithelial cells respond to adenovirus infections
Role of epithelial cell intracellular trafficking in the innate immune response to adenovirus infection
['FUNDING_R01'] · CASE WESTERN RESERVE UNIVERSITY · NIH-10755246
This study looks at how cells in your lungs respond to common viruses that can cause colds and other respiratory infections, focusing on a specific receptor that helps your immune system fight off these germs, with the hope of finding ways to boost your body's defenses against such infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10755246 on ClinicalTrials.gov |
What this research studies
This research investigates how epithelial cells in the respiratory tract interact with adenoviruses, which are common pathogens that can cause respiratory infections. It focuses on the role of the EGF receptor in the immune response of these cells when they encounter adenoviruses. By examining the cellular mechanisms and trafficking of the EGF receptor during infection, the research aims to uncover how these cells contribute to the body's initial defense against pathogens. Patients may benefit from insights gained about improving immune responses to respiratory infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing respiratory infections caused by adenoviruses.
Not a fit: Patients with non-respiratory conditions or those who do not have adenovirus infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing immune responses against adenovirus infections in patients.
How similar studies have performed: Previous research has shown promising results in understanding immune responses to viral infections, suggesting that this approach could yield valuable insights.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CARLIN, CATHLEEN R — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: CARLIN, CATHLEEN R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adenoviridae Infections, Adenovirus Infections