How epithelial cells contribute to chronic sinus inflammation
Epithelial cell complement production in the pathogenesis of chronic rhinosinusitis
['FUNDING_R01'] · UNIVERSITY OF FLORIDA · NIH-11016952
This study is looking at how certain cells in your sinuses might be causing inflammation in chronic rhinosinusitis by producing proteins that affect your immune system, with the goal of finding better treatments for people dealing with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-11016952 on ClinicalTrials.gov |
What this research studies
This research investigates the role of sinonasal epithelial cells in chronic rhinosinusitis (CRSwNP), focusing on how these cells produce complement proteins that may contribute to inflammation. The study aims to understand the mechanisms by which these cells respond to environmental triggers and how this affects immune responses in the sinus cavity. By examining the intracellular signaling pathways involved, researchers hope to uncover new insights into the dysregulation of these cells in patients with CRSwNP. This could lead to better-targeted therapies for managing chronic sinus conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic rhinosinusitis, particularly those with nasal polyps.
Not a fit: Patients without chronic rhinosinusitis or those with other unrelated sinus conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target the underlying causes of chronic rhinosinusitis, improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding the role of epithelial cells in immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MULLIGAN, JENNIFER KONOPA — UNIVERSITY OF FLORIDA
- Study coordinator: MULLIGAN, JENNIFER KONOPA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.