How epigenetics affects energy metabolism and liver health
Epigenetic Regulation of Mitochondrial Homeostasis and Energy Metabolism
This study is looking at how changes in our genes can affect energy use and liver health, especially for people with non-alcoholic fatty liver disease and insulin resistance, to help us understand more about the links to type 2 diabetes and other related health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10915562 on NIH RePORTER |
What this research studies
This research investigates the role of epigenetic modifications in regulating energy metabolism and liver health, particularly in the context of non-alcoholic fatty liver disease (NAFLD) and insulin resistance. By utilizing advanced techniques to map histone modifications in liver tissues, the study aims to identify key epigenetic factors that influence gene expression related to these conditions. The findings could provide insights into how these mechanisms contribute to the development of type 2 diabetes and related metabolic disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with non-alcoholic fatty liver disease or those experiencing insulin resistance.
Not a fit: Patients without metabolic disorders or those not affected by liver conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing or preventing type 2 diabetes and NAFLD.
How similar studies have performed: Previous research has shown promising results in understanding the epigenetic regulation of metabolic diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Yang, Qin — University of California-Irvine
- Study coordinator: Yang, Qin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.