How enzymes that change chromatin affect gene expression and cell development
Regulation of gene expression by chromatin remodeling enzymes
['FUNDING_OTHER'] · UNIV OF MASSACHUSETTS MED SCH WORCESTER · NIH-10775769
This study is looking at how certain enzymes help control gene activity as cells develop and change, which could help us understand diseases like cancer and improve treatments for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF MASSACHUSETTS MED SCH WORCESTER (nih funded) |
| Locations | 1 site (WORCESTER, UNITED STATES) |
| Trial ID | NIH-10775769 on ClinicalTrials.gov |
What this research studies
This research investigates the role of chromatin remodeling enzymes in regulating gene expression during cell differentiation and development. By focusing on the SWI/SNF enzyme family, the project aims to understand how these enzymes make DNA more accessible for transcription, which is crucial for normal cell function. The study will explore the interactions between these enzymes and various signaling pathways that influence their activity. Patients may benefit from insights gained about how misregulation of these enzymes can lead to diseases, including cancer.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with conditions linked to chromatin remodeling and gene expression abnormalities.
Not a fit: Patients with conditions unrelated to gene expression regulation or chromatin remodeling may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases related to gene expression misregulation, such as cancer.
How similar studies have performed: Previous research has shown that targeting chromatin remodeling enzymes can lead to significant advancements in understanding and treating various diseases, indicating a promising approach.
Where this research is happening
WORCESTER, UNITED STATES
- UNIV OF MASSACHUSETTS MED SCH WORCESTER — WORCESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: IMBALZANO, ANTHONY N — UNIV OF MASSACHUSETTS MED SCH WORCESTER
- Study coordinator: IMBALZANO, ANTHONY N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.