How enzymes help build ribosomes in human cells
Molecular mechanisms of ribosome biogenesis by force-producing enzymes
This study is looking at how our cells make ribosomes, which are important for building proteins, and it’s for anyone interested in finding new treatments for diseases like cancer that happen when ribosomes don’t work properly.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11018213 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms involved in the production of ribosomes, which are essential for protein synthesis in human cells. By focusing on ATP-driven enzymes, the study aims to understand how these enzymes facilitate the conversion of ribosomal precursors into mature ribosomes. The research employs advanced techniques, including single-molecule optical tweezers, to observe the actions of these enzymes in real-time. Ultimately, the goal is to develop new treatments for diseases related to ribosome dysfunction, such as certain cancers and ribosomopathies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with ribosomopathies or specific types of cancer that are associated with dysregulated ribosome production.
Not a fit: Patients with conditions unrelated to ribosome biogenesis or those not affected by cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies for cancers and genetic disorders linked to ribosome biogenesis.
How similar studies have performed: While the study of ribosome biogenesis is well-established, the specific focus on human systems and the use of advanced techniques represents a novel approach.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Mickolajczyk, Keith Joseph — Rutgers Biomedical and Health Sciences
- Study coordinator: Mickolajczyk, Keith Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.