How environmental toxicants affect genetic changes and cancer risk
STAG2 modulates environmental toxicant exposures and epigenomic heterogeneity
This study is looking at how being exposed to harmful chemicals like pesticides and heavy metals during important growth stages can affect health later on, especially in relation to cancer, and it aims to help people understand how these environmental factors might play a role in their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Roswell Park Cancer Institute Corp NIH-funded |
| Lab location | 1 site (Buffalo, United States) |
| Project ID | NIH-11002273 on NIH RePORTER |
What this research studies
This research investigates how exposure to environmental toxicants, such as pesticides and heavy metals, during critical developmental periods may lead to long-term health issues, including cancer. The study focuses on understanding the epigenetic changes that these toxicants induce, which can alter gene expression and potentially increase disease susceptibility. By using advanced cell and animal models, researchers aim to uncover the mechanisms behind these changes and their implications for cancer development. Patients may benefit from insights into how environmental factors contribute to their health conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of exposure to environmental toxicants, particularly during developmental stages.
Not a fit: Patients who have not been exposed to relevant environmental toxicants may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for diseases linked to environmental exposures.
How similar studies have performed: Previous research has shown that environmental exposures can lead to significant health impacts, suggesting that this approach may yield valuable insights.
Where this research is happening
Buffalo, United States
- Roswell Park Cancer Institute Corp — Buffalo, United States (Active)
Researchers
- Principal investigator: Ohm, Joyce Ellen — Roswell Park Cancer Institute Corp
- Study coordinator: Ohm, Joyce Ellen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.