How environmental iron affects Candida albicans and its interaction with the immune system during oral infections
Role of environmental iron in Candida albicans cell wall remodeling and its effect on host-pathogen interaction during oropharyngeal candidiasis
This study is looking at how different amounts of iron in the environment affect a type of yeast called Candida albicans, which can cause infections in people with weakened immune systems, to help find better ways to treat these infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10876395 on NIH RePORTER |
What this research studies
This research investigates how the presence of environmental iron influences the behavior of Candida albicans, a yeast that can cause infections in immunocompromised individuals. The study focuses on understanding the mechanisms by which iron levels affect the cell wall of the yeast, potentially altering its virulence and response to antifungal treatments. By conducting both in vitro experiments and using animal models, the researchers aim to uncover how variations in iron levels in the oral cavity can impact the severity of oropharyngeal candidiasis. This could lead to new strategies for managing infections in vulnerable populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are immunocompromised individuals or diabetics who are at risk for oropharyngeal candidiasis.
Not a fit: Patients who do not have oropharyngeal candidiasis or are not immunocompromised may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients suffering from oropharyngeal candidiasis by targeting iron levels to control fungal virulence.
How similar studies have performed: While the specific focus on iron's role in Candida albicans during oropharyngeal candidiasis is novel, related research has shown that manipulating environmental factors can influence fungal behavior and virulence.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Puri, Sumant — Temple Univ of the Commonwealth
- Study coordinator: Puri, Sumant
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.