How environmental heat affects stroke outcomes in Alzheimer's disease patients
Official title: Impact of Environmental Stressors on Ischemic Stroke Outcome Inequities in Alzheimers Disease and Related Dementias
Funded at Feinstein Institute for Medical Research · NIH-10977706 · Data updated 2026-11-12
This study is looking at how hot weather and tough living conditions affect people with Alzheimer's and related dementias who have had a stroke, to see if those factors make their strokes worse and recovery harder, with the goal of helping to find better ways to care for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $502,929 |
| NIH project number | 1R01NS139190-01 |
| Project ID | NIH-10977706 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias who reside in socioeconomically disadvantaged neighborhoods prone to high temperatures.
✕Less likely to help
Patients with Alzheimer's disease or related dementias living in areas not affected by significant heat exposure or socioeconomic stressors may not benefit from this research.
What this research studies
This research investigates the impact of environmental heat and socioeconomic stressors on the outcomes of ischemic stroke in individuals with Alzheimer's disease (AD) and related dementias (ADRD). It aims to evaluate how living in neighborhoods with high heat vulnerability correlates with increased stroke severity and poorer recovery outcomes. By analyzing data from various neighborhoods, the study will assess the combined effects of heat exposure and socioeconomic factors on stroke morbidity and mortality in this vulnerable population. The findings could help identify at-risk patients and inform interventions to improve their care.
Why it matters
Potential benefit: If successful, this research could lead to targeted strategies that improve stroke outcomes for patients with Alzheimer's disease and related dementias living in high-risk environments.
How similar studies have gone: While the individual impacts of heat and socioeconomic stressors on stroke outcomes have been studied, this research is novel in its combined approach to evaluate their joint effects on patients with Alzheimer's disease and related dementias.
Where this research is happening
-
Feinstein Institute for Medical Research
Manhasset, United States Active
Researchers
- Principal investigator: Sanelli, Pina Christine — Feinstein Institute for Medical Research
- Study coordinator: Sanelli, Pina Christine
Related research
Other NIH-funded projects on the same topics.
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Heat and neighborhood stressors worsen stroke outcomes in people with Alzheimer’s and related dementias
In people with Alzheimer’s disease or related dementias, this project studies how hot weather and neighborhood-level socioeconomic stress affect stroke outcomes.
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How heat and neighborhood stress affect stroke recovery in people with Alzheimer's
Researchers will look at whether living in hot, high-stress neighborhoods makes strokes more likely or harder to recover from for people with Alzheimer's or related dementias.
-
Improving blood flow after stroke by breaking down NETs
Aims to see if breaking down neutrophil extracellular traps (NETs) after an ischemic stroke can improve blood flow and reduce brain injury in patients.
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EP2 blockers to protect the brain after a stroke
Aims to test brain-permeable EP2 antagonists to reduce damage after ischemic stroke and improve recovery.
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Genetic testing to find causes of early-onset ischemic stroke
This project uses whole-exome sequencing to look for gene changes that may cause ischemic stroke in adults who had a stroke at a young age.
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Targeted nanomedicine to protect the brain after stroke
A targeted drug-delivery approach aims to boost blood-brain barrier repair and reduce brain damage after an acute ischemic stroke in patients at risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.