How environmental factors and certain molecules affect the progression of aggressive breast cancer in African American women.
Official title: Interactions between ES-miRNAs and environmental risk factors are responsible for TNBC progression and associated racial health disparities: a novel analysis with multilevel moderation inferences
Funded at Lsu Health Sciences Center · NIH-11006247 · Data updated 2026-11-12
This study is looking at how things in our environment might affect certain tiny molecules related to triple-negative breast cancer, especially in African American women, to find ways to improve treatment and outcomes for those facing this type of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Health Sciences Center NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | January 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $336,263 |
| NIH project number | 5R01CA275089-03 |
| Project ID | NIH-11006247 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are African American women diagnosed with triple-negative breast cancer.
✕Less likely to help
Patients who do not have triple-negative breast cancer or are not African American women may not benefit from this research.
What this research studies
This research investigates the relationship between environmental risk factors and specific molecules called exosomal microRNAs in the progression of triple-negative breast cancer (TNBC), particularly among African American women. The study aims to understand how these factors contribute to the higher rates of advanced TNBC in this population. By analyzing data from various neighborhoods, the researchers will explore how social and physical environments influence cancer outcomes. The goal is to identify modifiable factors that could improve prognosis and treatment options for patients.
Why it matters
Potential benefit: If successful, this research could lead to targeted interventions that improve outcomes for African American women diagnosed with triple-negative breast cancer.
How similar studies have gone: Previous studies have shown that understanding the interplay between environmental factors and cancer progression can lead to significant advancements in treatment strategies, suggesting this approach has potential for success.
Where this research is happening
-
Lsu Health Sciences Center
New Orleans, United States Active
Researchers
- Principal investigator: Yu, Qingzhao — Lsu Health Sciences Center
- Study coordinator: Yu, Qingzhao
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.