How environmental factors affect DNA stability in BRCA1 gene mutation carriers
Official title: Environmental factors and compounds affecting the genomic stability in haploinsufficient BRCA1 cells.
Funded at Weill Medical Coll of Cornell Univ · NIH-10735532 · Data updated 2026-11-12
This study is looking at how things in our environment and what we eat can affect the DNA of people with a BRCA1 gene mutation, which can increase their cancer risk, and it hopes to find ways to help protect their DNA and reduce damage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 7, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $1,114,041 |
| NIH project number | 1R01ES034733-01A1 |
| Project ID | NIH-10735532 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are BRCA1 mutation carriers and are at increased risk for developing breast or other cancers.
✕Less likely to help
Patients without BRCA1 mutations or those who do not have a family history of related cancers may not benefit from this research.
What this research studies
This research investigates how environmental factors and dietary agents influence genomic stability in individuals with mutations in the BRCA1 gene, which is linked to a higher risk of cancer. The study will explore the biological mechanisms behind DNA replication and repair defects in BRCA1 haploinsufficient cells, particularly focusing on how these factors contribute to cancer development. Additionally, it aims to identify dietary agents that may help reduce DNA damage and improve genomic stability in these patients.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cancer in individuals with BRCA1 mutations by identifying protective dietary agents.
How similar studies have gone: While research on BRCA1 mutations is extensive, the specific focus on environmental factors and dietary agents in this context is relatively novel and has not been extensively tested.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Gerhardt, Jeannine — Weill Medical Coll of Cornell Univ
- Study coordinator: Gerhardt, Jeannine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.