How environmental factors affect brain development and autism
Developmental neurotoxicity and autism spectrum disorder
This study is looking at how both genes and the environment, like exposure to certain metals, affect brain development in people with autism, and it hopes to find new ways to understand and help those with the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Medical Sciences, Ondo NIH-funded |
| Lab location | 1 site (Ondo, Nigeria) |
| Project ID | NIH-10886734 on NIH RePORTER |
What this research studies
This research investigates the impact of genetic and environmental factors on brain development, particularly focusing on autism spectrum disorder (ASD). The principal investigator, Dr. Omamuyovwi Ijomone, will utilize a model organism called Caenorhabditis elegans to explore how exposure to heavy metals like nickel and manganese during critical developmental stages can lead to neuronal degeneration. By examining specific genes associated with ASD, the research aims to uncover the mechanisms behind neurodevelopmental disorders. Patients may benefit from insights that could lead to better understanding and potential interventions for ASD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autism spectrum disorder or those at risk due to environmental exposures.
Not a fit: Patients who do not have autism spectrum disorder or are not exposed to the environmental factors being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide valuable insights into the causes of autism spectrum disorder, potentially leading to improved prevention and treatment strategies.
How similar studies have performed: While the use of Caenorhabditis elegans in neurodevelopmental research is established, the specific focus on ASD and the environmental factors in this context is relatively novel.
Where this research is happening
Ondo, Nigeria
- University of Medical Sciences, Ondo — Ondo, Nigeria (Active)
Researchers
- Principal investigator: Ijomone, Omamuyovwi Meashack — University of Medical Sciences, Ondo
- Study coordinator: Ijomone, Omamuyovwi Meashack
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.