How Environmental Damage to Our DNA Leads to Cancer
Environmental DNA Lesions and Mutagenesis: Molecular Mechanisms of Lesion Recognition for Repair and Polymerase Bypass
['FUNDING_R01'] · NEW YORK UNIVERSITY · NIH-11078314
This project explores how environmental factors harm our DNA and how our bodies try to fix or work around this damage, which can lead to cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11078314 on ClinicalTrials.gov |
What this research studies
Our DNA is constantly exposed to harmful substances from the environment, such as pollutants, certain medicines, and UV light. These exposures create 'lesions' or damage in our DNA, which can cause changes (mutations) that lead to cancer. Our bodies have natural ways to fix this damage through repair mechanisms or to work around it, but some damage is harder to fix or bypass, making it more likely to cause cancer. This project aims to uncover the exact steps involved in how our bodies recognize and deal with this DNA damage, helping us understand why some damage is more dangerous than others.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this foundational research.
Why it matters
Potential benefit: Understanding these fundamental mechanisms could lead to better strategies for preventing or treating cancers caused by environmental DNA damage.
How similar studies have performed: This project addresses significant gaps in our current understanding of DNA damage and repair, building on existing knowledge but exploring new mechanistic insights.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BROYDE, SUSE — NEW YORK UNIVERSITY
- Study coordinator: BROYDE, SUSE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Anti-Cancer Agents