How environmental chemicals affect chronic diseases through bioactive lipids
Official title: Bioactive lipids as effectors and indicators of the deleterious effects of environmental exposure on chronic diseases
Funded at University of California at Davis · NIH-11083623 · Data updated 2026-11-12
This study is looking at how certain chemicals in our environment might affect our health by changing important fats in our bodies, which could lead to diseases like diabetes, heart problems, and cancer, and it’s for anyone interested in understanding how these toxins might impact their health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | June 15, 2019 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $1,026,770 |
| NIH project number | 5R35ES030443-07 |
| Project ID | NIH-11083623 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are individuals suffering from chronic diseases such as diabetes, heart failure, or cancer, particularly those with a known history of environmental exposure.
✕Less likely to help
Patients with acute conditions unrelated to chronic diseases or environmental factors may not benefit from this research.
What this research studies
This research investigates the impact of environmental chemicals on chronic diseases by focusing on lipid chemical mediators known as oxylipins. It aims to understand how these toxins can disrupt regulatory systems in the body, leading to conditions such as diabetes, heart failure, and cancer. The study will utilize inhibitors to stabilize beneficial lipids and assess their effects on various disease models. By monitoring the levels of these lipids and other mediators, the research seeks to uncover biochemical mechanisms that link environmental exposure to chronic health issues.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing chronic diseases linked to environmental exposures.
How similar studies have gone: Previous research has shown promising results in using similar approaches to stabilize beneficial lipids for treating chronic diseases.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Hammock, Bruce D — University of California at Davis
- Study coordinator: Hammock, Bruce D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.