How environmental changes affect mutations in viruses
Effects of The Rate of Environmental Change on Mutational Patterns and Evolutionary Constraints
['FUNDING_OTHER'] · SAN JOSE STATE UNIVERSITY · NIH-10874469
This study looks at how quickly changes in the environment, like temperature, can affect the way RNA viruses, such as the bacteriophage ɸ6 Cystovirus, mutate and adapt, which could help us find better ways to treat viral infections.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SAN JOSE STATE UNIVERSITY (nih funded) |
| Locations | 1 site (SAN JOSE, UNITED STATES) |
| Trial ID | NIH-10874469 on ClinicalTrials.gov |
What this research studies
This research investigates how different rates of environmental change influence the genetic mutations in RNA viruses, specifically focusing on the bacteriophage ɸ6 Cystovirus. By comparing viral populations that have been exposed to sudden versus gradual increases in temperature, the study aims to understand the mechanisms of adaptation and the role of genetic interactions. Patients may benefit from insights gained about viral evolution, which could inform treatment strategies for viral infections. The research employs advanced genetic analysis to evaluate mutation patterns and their implications for virus behavior in changing environments.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals affected by viral infections, particularly those caused by RNA viruses.
Not a fit: Patients with non-viral infections or conditions unrelated to viral evolution may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of viral adaptation, potentially enhancing treatment options for viral infections.
How similar studies have performed: While the specific approach of examining RNA virus mutations under varying environmental conditions is relatively novel, similar studies have shown promising results in understanding viral evolution.
Where this research is happening
SAN JOSE, UNITED STATES
- SAN JOSE STATE UNIVERSITY — SAN JOSE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SINGHAL, SONIA — SAN JOSE STATE UNIVERSITY
- Study coordinator: SINGHAL, SONIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.