How environmental changes affect mutations in viruses
Official title: Effects of The Rate of Environmental Change on Mutational Patterns and Evolutionary Constraints
Funded at San Jose State University · NIH-10874469 · Data updated 2026-11-12
This study looks at how quickly changes in the environment, like temperature, can affect the way RNA viruses, such as the bacteriophage ɸ6 Cystovirus, mutate and adapt, which could help us find better ways to treat viral infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | San Jose State University NIH-funded |
| Lab location | 1 site (San Jose, United States) |
| Project start | July 15, 2022 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $183,125 |
| NIH project number | 5R16GM146706-03 |
| Project ID | NIH-10874469 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals affected by viral infections, particularly those caused by RNA viruses.
✕Less likely to help
Patients with non-viral infections or conditions unrelated to viral evolution may not receive any benefit from this research.
What this research studies
This research investigates how different rates of environmental change influence the genetic mutations in RNA viruses, specifically focusing on the bacteriophage ɸ6 Cystovirus. By comparing viral populations that have been exposed to sudden versus gradual increases in temperature, the study aims to understand the mechanisms of adaptation and the role of genetic interactions. Patients may benefit from insights gained about viral evolution, which could inform treatment strategies for viral infections. The research employs advanced genetic analysis to evaluate mutation patterns and their implications for virus behavior in changing environments.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of viral adaptation, potentially enhancing treatment options for viral infections.
How similar studies have gone: While the specific approach of examining RNA virus mutations under varying environmental conditions is relatively novel, similar studies have shown promising results in understanding viral evolution.
Where this research is happening
-
San Jose State University
San Jose, United States Active
Researchers
- Principal investigator: Singhal, Sonia — San Jose State University
- Study coordinator: Singhal, Sonia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.