How enteroviruses spread and affect different cells and tissues over time
Mapping spatiotemporal dynamics during enterovirus infection across cells and tissues
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11404873
This project looks at how common enteroviruses behave and change inside the bodies of infants and adolescents who get infections like hand‑foot‑and‑mouth disease or EV‑D68.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11404873 on ClinicalTrials.gov |
What this research studies
From a patient point of view, researchers will map where and when enteroviruses appear in different tissues and which cell types they infect during the course of illness. They will use single‑cell RNA sequencing to measure viral levels and the host response in individual cells and tissues over time. In parallel, investigators will use ultra‑deep viral sequencing to track how the virus mutates within a person and apply deep‑learning methods to integrate these data. The goal is to build detailed, time‑resolved maps of infection for viruses such as CVB3, EV‑D68 and EV‑A71.
Who could benefit from this research
Good fit: Ideal participants would be children or adolescents (and possibly adults) with recent or current enterovirus infections, or people willing to provide relevant clinical samples or tissue at participating sites.
Not a fit: People without enterovirus infection or those needing immediate clinical treatment are unlikely to receive direct benefit from participation in this basic‑science project.
Why it matters
Potential benefit: If successful, this work could lead to better diagnostics, clearer explanations of why some infections become severe, and new targets for treatments or prevention.
How similar studies have performed: Single‑cell profiling and deep viral sequencing have helped clarify other viral infections, but combining ultra‑deep viral population sequencing with single‑cell maps for enteroviruses is a relatively new and novel approach.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ANDINO, RAUL — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: ANDINO, RAUL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.